Predisposing gene for OA in several previous studies and encodes aĬartilage extracellular protein belonging to the small leucine-rich The asporin (ASPN) gene has been reported as a Would prove helpful in the early diagnosis of OA. Particularly genetic factors strongly affect the occurrence andĭevelopment of OA ( 14, 15). Studies have shown that age, sex, obesity, genetics, ethnicity,īehavioral influences, occupation and environmental factors, and
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Polygenic and multifactorial illness ( 11– 13). Identify early stage onset and progression ( 10). In clinical practice,ĭiagnosis of OA is based mainly on radiological examination andĬlinical assessment, and a key point for OA diagnosis is to Incidence of OA increases year after year. Incidence rate of 40% in the 55–64 age group ( 9). Moreover, according to the World Health Organization (WHO), OA hasīeen the fourth major cause of disability for many years, with an That approximately 10% of the world's population aged over 60 years Locking may also occur, which will cause more serious painĭecrease quality of life. When the bare bony surfaces grate against each other, The articulation may show some swelling caused by an effusion and Degradation of hyaline articularĬartilage and remodeling of the subchondral bone with sclerosis are Spine, thus constituting a leading cause of musculoskeletalĭisability worldwide ( 1, 2). Occur in any joint but primarily affects knees, hips, hands and the As the most frequent form of joint disease, OA can Osteoarthritis (OA) is a common disease of the However, the mechanisms contributing to the association between ASPN polymorphisms and OA risk still require further study. The results of the meta‑analysis verified that ASPN polymorphisms were not significantly relevant to an increased OA risk. Results of the multivariate meta‑regression analysis revealed that the study sample size was a source of heterogeneity between studies. Following document retrieval and screening, a total of 10 studies were deemed eligible, including 4,842 patients and 3,661 healthy subjects.
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Begg's funnel plots and Egger's tests were used to assess publication bias in the present meta‑analysis. A random‑effects model was used in a pooled analysis to adjust for heterogeneity of the included studies, and the differences between treatment groups were reported as odds ratio (OR), 95% confidence intervals (CIs) and P‑values. The K/L grading system, clinical and radiological diagnoses were used for OA diagnosis. Cohort and case‑control studies that explored the association between different types of ASPN alleles and OA susceptibility were evaluated. The current study searched the literature from January 1st, 1915 through February 1st, 2017 using the Cochrane Library, PubMed, the Excerpta Medica database (EMBASE) and three main Chinese databases (VIP, CNKI and Wan Fang). To provide an evidence-based medical basis for the treatment of osteoarthritis, a meta‑analysis was performed to assess the association between asporin (ASPN) gene polymorphism and susceptibility to osteoarthritis (OA).